Open Access Letter to the Editor

A Rare Complication after Liver Biopsy; Septic Shock Secondary to Hemobilia

Gulhan Kanat Unler

International Research Journal of Gastroenterology and Hepatology, Page 17-19

The “Type of Article” of this paper is “Letter to the Editor”. This paper discuses about: “A Rare Complication after Liver Biopsy; Septic Shock Secondary to Hemobilia”. No formal abstract is available. Readers are requested to read the full article.

Open Access Case Report

Acute Intestinal Obstruction on a Spontaneous Intra-Parietal Hematoma: Rare Complication Induced by Anti-coagulant Therapy

Mounir Bouali, Issam Hamrerras, Abdoulaye Harouna Bonkoukou, Abdelillah El. Bakouri, Fatimazahra Bensardi, Khalid El. Hattabi, Abdelaziz Fadil

International Research Journal of Gastroenterology and Hepatology, Page 1-5

The acute bowel occlusion for the small intestine parietal hematoma due to anticoagulant treatment or vitamin K antagonists (VKA) is a rare pathology. Few cases have been reported in literature. The often clinical presentation is an acute abdomen. The evolution under medical treatment (conservative treatment) is favorable. In few cases, there is a persistance of occlusion and the surgical treatment is indicated. We report a case of a 67 year old male patient, known to have valvulopathy under VKA, who presented an intestinal occlusion due to parietal hematoma discovered on abdominal CT and who benefited medical treatment with a favorable evolution.

Open Access Case Report

Thoracic Empyema Revealing a Fistulized Splenic Abscess: A Rare Case

Hamza El Kihal, Issam Hamrerras, Hajar Arfaoui, Hasna Jabri, Wiam El Khattabi, Hicham Afif, Mounir Bouali, Abdelillah El Bakouri, Fatimazahra Bensardi, Khalid El Hattabi, Abdelaziz Fadil

International Research Journal of Gastroenterology and Hepatology, Page 6-10

Subphrenic abscesses, like the splenic abscess, is a collection of infectious origin. It is rare and potentially severe due to local complications. Its diagnosis is difficult given the variable clinical symptomatology. The abdominal computed tomography poses the diagnosis with certainty. It requires emergency medical and surgical treatment. We report the case of a patient with a splenic abscess discovered fortuitously following the radiological exploration of thoracic empyema. The surgical procedure consisted of a total splenectomy with suture of the diaphragmatic fistula and chest drainage of the empyema. The postoperative suites were favourable after 2-year of follow-up.

The splenic abscess is a cause of thoracic empyema and its rupture through a diaphragmatic breach remains a rare etiology, requiring emergency medical and surgical management.

Open Access Original Research Article

Hepatitis B Infection among Commercial Sex Workers in Lyantonde Town, Central Uganda: Prevalence, Knowledge and Practices

Erick Thokerunga, Akatujuna Asumprisio, Semakula Dennis, Abomugisha Innocent, Yikita Derrick, Simon Peter Rugera, Gilbert Akankwatsa

International Research Journal of Gastroenterology and Hepatology, Page 11-16

Aims: The study was conducted to determine the prevalence of hepatitis B infection among female commercial sex workers in Lyantonde town.

Study Design:  A cross sectional study was conducted.

Place and Duration of Study: The study was carried out in Lyantonde town, Lyantonde district, central Uganda, from November 2019 to January 2020.

Methodology: Included were 207 consented commercial sex workers operating in Lyantonde town at the time of the study. A structured questionnaire was administered to collect information on bio-data, knowledge on hepatitis B infection and practices. Blood samples were then collected and transported to Mbarara Regional Referral Hospital Laboratory for analysis.

Results: Hepatitis B prevalence of 12.6% was established among the commercial sex workers. 207 participants with a mean age of 26±3.801 were studied. 28.0% were married, 30.4% cohabiting, 12.1% single and 29.5% divorced. 15.0% had no formal education, 28.5% had primary level education and 56.5% had secondary level education. 60.4% lived on less than one dollar a day.

All the participants had ever heard of hepatitis B infection. 95.6% had awareness of its sexual transmission, 44.9% knew it spreads through sharing sharps, 4.8% had awareness of mother to child transmission during child birth and 38.6% thought the disease is unpreventable.

Thirty-five-point seven percent (35.7%) had ever tested for the disease but none vaccinated. All the participants reported irregular condom use during sex and non-confessed to intravenous or illicit drug use. 61.8% expressed desire to giving birth at home and not a hospital.

Conclusion: Hepatitis B infection at 12.6% is highly prevalent among female commercial sex workers in Lyantonde town majority of whom are unaware of their status and do not consistently practice safe sex e.g. condom use. A targeted testing and vaccination program including prevention awareness campaigns could go a long way in keeping this marginalized population safe.

Open Access Original Research Article

Hepatoprotective, Antioxidant and Hypolipidemic Potentials of Mucuna pruriens in a Diabetic Experimental Animal Model

Raymond C. Ibeh, Henry N. Ogbonna, Godwin S. Aloh, Chinedu P. Nwuke, Gavin C. Ikechukwu, Onyinye E. Eziefuna, Daniella O. Dialah, Isaac C. Usuka, Kalu Precious Nkemjika, Caryne C. Ezerioha

International Research Journal of Gastroenterology and Hepatology, Page 20-29

Aims: This study investigates the effect of Mucuna pruriens leaves on the liver, antioxidant parameters and lipid profile of alloxan-induced diabetic rats.

Methodology: Thirty-five (35) Wistar albino rats were divided into five groups with seven (7) rats per group. The experiment was designed as follows: Group 1 – NC, Normal Control; Group 2 – DBC, Diabetic Control; Group 3 -  DG, Diabetic glibenclamide (Positive control); Group 4 - DMPL (Diabetic Mucuna pruriens extract Low – 50 mg/kg); Group 5 - DMPH (Diabetic Mucuna pruriens extract High – 100 mg/kg). The rats were fed with normal feed and drinking water ad libitum. The diabetic control, diabetic glibenclamide and the extract groups (50 mg/kg and 100 mg/kg) were induced with diabetes by intraperitoneal injection of 120 mg/kg bodyweight of alloxan monohydrate and confirmation was done using a glucometer. The positive control was treated with glibenclamide (6 mg/65 kg/day). Blood samples were collected from seven (7) rats in each group through the retro-orbital plexus of the eye after 28 days of treatment, thereafter, the rats were sacrificed by cervical dislocation under light ether anesthesia, and biochemical parameters were determined using standard techniques (Randox kits).

Results: Mucuna pruriens leaf extract lowered blood glucose levels across the groups treated with the extract. The diabetic rat fed with Mucuna pruriens extracts showed a significant (p<0.01) reduction in hepatic ALT (Alanine Transaminase), AST (Aspartate Transaminase) and ALP (Alkaline Phosphatase) when compared to the diabetic control. Compared to the diabetic control, the extract groups showed a significant (p<0.05) reduction in serum Low-density lipoprotein (LDL) and total cholesterol with a significant (p<0.05) increase in HDL. The extract groups showed marked dose-dependent significant (p<0.05) increase in GPx over all other groups, and a significant (p<0.05) decrease in Malonaldehyde level when compared to the diabetic control group. There was no significant (p>0.05) difference in the levels of Catalase, Superoxide dismutase, and Glutathione across the groups. There is a significant (p<0.05) increase in the level of Vitamin E of extract groups when compared to the diabetic control and diabetic glibenclamide group with a significant increase (p<0.05) in Vit. C level of extract group (50 mg/kg) when compared to all other groups.

Conclusion: This result of the study suggests that Mucuna pruriens have a beneficial effect on the hepatocyte and some lipid profile parameters while also increasing antioxidant defense of the body and may be of value in the management of diabetes and its complications.