Open Access Case Study

A Rare Reason of Intestinal Obstruction: Abdominal Cocoon Due to Tuberculosis

Mehmet Akif Aydin, Hüseyin Akyol, Muhammet Fatih Aydin

International Research Journal of Gastroenterology and Hepatology, Page 1-4

The abdominal cocoon is a rare cause of intestinal obstruction. There are many causes in the etiology, tuberculosis is one of them. The abdominal cocoon is treated conservatively or surgically according to the degree of intestinal obstruction and etiology. For this reason, it is important to diagnose before treatment. Herein, We present a rare case of abdominal cocoon due to abominal tuberculosis.

Open Access Case Study

Intrahepatic Multicystic/ Biliary Hamartomas: Presentation of a Case Report and Magnetic Resonance Imaging /Magnetic Resonance Cholangiopancreatography Findings

Eylem Karatay

International Research Journal of Gastroenterology and Hepatology, Page 1-7

Biliary hamartomas, known as von Meyenburg complexes (VMCs), are benign liver malformations. They are histologically characterized by cystic dilated bile ducts surrounded by numerous fibrous stromal elements measuring up to 5 mm in diameter. Incidental detection of VMCs by autopsy is difficult. Detection of VMCs by imaging is also difficult because of their asymptomatic nature and small size and also the rarity. Moreover, they are easily confused with metastatic diseases of the liver, especially on imaging.

A 39-year-old man presented to our hospital with a 6-month history of recurrent nonspecific abdominal pain. Abdominal ultrasonography (US) revealed multiple cystic lesions in the liver. The diagnosis of metastases was suggested. However, the final diagnosis of VMCs was confirmed by magnetic resonance imaging and magnetic resonance cholangiopancreatography.

This case report highlights the routine differential diagnosis of biliary hamartomas by magnetic resonance imaging and magnetic resonance cholangiopancreatography.

Open Access Original Research Article

Association between Hepatitis C Virus Infection and the Immunologic, Hematologic Parameters in HIV-Positive Adults in a Tertiary Health Facility in Southeastern Nigeria

B. O. Amechi, E. O. Obiorah

International Research Journal of Gastroenterology and Hepatology, Page 1-7

Background: Three-quarters of liver-related diseases and deaths are caused by Hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV) infected individuals. Data on HCV and HIV co-infection in Nigeria in general and Umuahia metropolis, in particular, are scarce. Thus, to close this gap, we examined the relationship between HCV- infection and the immunologic, hematologic profile of HIV- infected patients, and determined the prevalence of HCV infection among patients.

Methods: This cross-sectional study examined 143 blood samples of HIV-infected patients 18 years and older collected between August 2016 and November 2016 in the ART clinic of the Federal Medical Centre, Umuahia, Nigeria. We analyzed samples for HCV antibodies using the rapid ELISA technique; CD4 count using the Cyflow machine, white blood cell count (WBC) and packed cell volume (PCV) using the Sysmex machine. Prevalence and associations were determined using frequency distribution and χ2 test and α level set at .05.

Results: One hundred and eighteen (83%) subjects were on ART and 25 (18%) non-ART. Fifty two (36%) subjects were males and 91 (64%) were females. The age range was 18 - 71 years and a mean of 40.64 years. HCV prevalence was 14%. Prevalence by gender was 11% male and 15% female. Prevalence by ART status was 60.0% ART and 3.4% Non-ART. There was statistically significant associations between HCV and ART status (χ2 = 32.3, P= .001); between HCV and CD4 cell count (χ2 = 8.87, P = .031) but no associations between HCV and WBC (χ2 = 1.615, P > .05) and PCV (χ= 1.002, P > .05). Prevalence was more in the CD4 ≤ 200 cells/ml groups (40%) and the 31-50 age groups (40.0%).

Conclusion: HCV/HIV co-infection was associated with low CD4 cell count and being female. It is therefore essential to maintain the CD4 cell of HIV-positive individuals at a number> 300 cells/ml to prevent possible co-infection with HCV, and this will help avoid additional disease and financial burden on people living with HIV/AIDS in Nigeria.

Open Access Original Research Article

Hepatocellular Carcinoma in Hepatitis C Virus Infected Patients and Interleukin-28B Gene Polymorphism: A Controversy Relationship

Fadia M. Attia, Adel A. Hassan, Fawzy A. Khalil, Mona I. Salama, Hala Sabry, Hamdy Sliem

International Research Journal of Gastroenterology and Hepatology, Page 1-9

Background: Hepatocellular carcinoma (HCC) is considered as one of the most common cancer worldwide for approximately 5.6% of all cancers, it is the third common cause of cancer death.  It considers the most serious complication of hepatitis C virus infection, because the onset of the disease occurs slowly, many patients are unaware of their infection and at least 40% cases remain undetected.

Aim: This study was carried out to evaluate the association of IL28B gene polymorphism with HCC in HCV infected Egyptian patients in HCV genotype-4 infection.

Methods: This cross-sectiona, case control study was conducted on three groups. Group I (HCC cases among positive HCV antibody patients), Group II (positive HCV  antibody patients with no hepatic focal lesion), and Group III (healthy individuals).Extracted DNA for each individual was examined for IL-28B rs8099917 SNP. The analysis was performed using taqman technique.

Results: The percentage of genotype IL-28B rs8099917 in the studied groups was statistically investigated which showed homo (TT) in (100%) in the control group and the polymorphism showed statistically significant different among the study groups (p value < 0.016). IL-28B rs8099917 allelic discrimination was reinvestigated again between HCC group and HCV group only but it showed no significant difference (p value = 0.814). The polymorphisms of IL-28B rs8099917 was statistically investigated regarding to clinical data of HCC group but it showed no significant difference.

Conclusion: IL-28B rs8099917 genotype showed a significant difference between HCV positive patients (either with HCC or without) compared with healthy people.