International Research Journal of Gastroenterology and Hepatology 2020-10-21T06:05:44+00:00 International Research Journal of Gastroenterology and Hepa Open Journal Systems <p style="text-align: justify;"><strong>International&nbsp;&nbsp;Research Journal of Gastroenterology and Hepatology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/IRJGH/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Gastroenterology and Hepatology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Case of Eosinophilic Ascites Secondary Surgical Sponge 2020-10-21T06:05:44+00:00 Gulhan Kanat Unler Huseyin Savaş Gokturk Esra Zeynep Coskunoglu <p>The “Type of Article” of this paper is “<span class="il">Letter</span>&nbsp;to the&nbsp;<span class="il">Editor</span>”. This paper discuses about: “<strong>Case of Eosinophilic Ascites Secondary Surgical Sponge</strong>”. No formal abstract is available. Readers are requested to read the full article.</p> 2020-10-21T00:00:00+00:00 ##submission.copyrightStatement## Hepatitis B and C Status and Associated Risk Factors among Migrant Female Head Porters [Kayayei] within La-Nkwantanang Madina Municipality, Ghana 2020-08-21T07:41:28+00:00 Lawrence Quaye Yussif Adams Peter Paul M. Dapare Simon Bannison Bani Moses Banyeh Osman Samira <p><strong>Aim:</strong> This study was conducted to determine the knowledge, prevalence and associated risk factors of viral hepatitis among migrant female head porters (Kayayei) in La-Nkwantanang Madina municipality of the Greater Accra region, Ghana.</p> <p><strong>Study Design:</strong> A descriptive cross-sectional study was conducted.</p> <p><strong>Place and Duration of Study:</strong> The study was carried out at three market centers [Atima, La-Nkwantanang and Madina markets] within the La-Nkwantanang Madina municipality of the Greater Accra region, Ghana.</p> <p><strong>Methodology:</strong> A total of 125 kayayei residing and working in La-Nkwantanang Madina municipality were included at the time of the study. A semi-structured questionnaire and focus group discussions were adopted to collect demographic and knowledge data while blood samples were drawn from each participant for hepatitis B and C assays.</p> <p><strong>Results:</strong> Results from the study shows, prevalence of hepatitis B was 7.2% and that for hepatitis C was 6.4% respectively. One (0.8%) person was co-infected with hepatitis B and C virus. Majority (73.6%) of kayayei had no knowledge on viral hepatitis and its spread with risk factors associated with hepatitis virus were; unprotected sexual intercourse (OR = 2.93, 95% CI = 1.032-8.288) and multiple sexual partners (OR = 5.23, 95% CI = 1.302-21.02).</p> <p><strong>Conclusion:</strong> Viral hepatitis infection is common among kayayei and the level of knowledge of this disease is low. The study recommends; regular sensitization on adolescent and reproduction health among these vulnerable group and educational programs on negative the effects of child labour extended to parents in northern Ghana to discourage their daughters from migrating to the cities for head porterage but rather stay in school. Again, future research prospects can look at prevalence of comorbidity of HIV and Hepatitis as well as human papillomaviruses (HPVs) among these vulnerable group.</p> 2020-08-21T00:00:00+00:00 ##submission.copyrightStatement## Hepatoprotective Effects of Hypoestes rosea in Acetaminophen-Induced Toxicity in Albino Rats 2020-10-01T11:36:39+00:00 Ogregade, I. E. Igwe, F. Davies, T. G. Bartimaeus, E. S. <p><strong>Aims: </strong>The aim of this study was to evaluate the hepatoprotective effects of <em>Hypoestes rosea</em> in acetaminophen-induced toxicity in albino rats.</p> <p><strong>Study Design:</strong>&nbsp; This study is a case-controlled interventional study.</p> <p><strong>Place and Duration of Study:</strong> This study was conducted at the Experimental Animal Unit of the Department of Human Physiology, University of Port- Harcourt, between June 2018 and December, 2019.</p> <p><strong>Methodology:</strong> A total of 112 adult apparently healthy albino rats weighing (180-220 g) were used for this study, the rats were divided into six experimental groups of extract control (EC), negative control (NC), positive control (PC), aqueous extract of <em>Hypoestes rosea</em> (AEHr) 100 mg/kg body weight (b w), AEHr 200 mg/kg b w., and AEHr 300 mg/kg b w. groups each of six rats. The study groups comprised of two treatment phases each, (Pre-treatment and Post-treatment phases), duration of treatment (Acute and Sub-chronic) with six experimental groups in each of the phases.&nbsp;&nbsp; At the end of the study period, blood sample were taken through jugular vein under chloroform anaesthesia in a desiccator for liver function parameters Total Bilirubin (TB), Conjugated Bilirubin (CB), Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT), Alkaline phosphatase (ALP), 5’-Nucleotidase (5’NT), Lactose Dehydrogenase (LDH), Gamma Glutamyl Transpeptidase (GGT), Total Protein (TP), Albumin (ALB) analyses using auto analyzer and AST/ALT was calculated. Liver of rats were also harvested for histology study. Statistical analysis was performed using SPSS version 23 and p &lt;0.05 was considered statistically significant.</p> <p><strong>Results:</strong> Results showed that acetaminophen induced toxicity in albino rats caused hepatotoxicity as evidenced by significant elevation of TB, CB and liver enzymes with a significantly reduced TP and ALB levels (p&lt;0.05) in the PC group when compared with other experimental groups. However, various concentrations of aqueous extract of <em>Hypoestes rosea</em> in a dose dependent pattern at the different treatment phases at acute and sub-chronic period was able to restore the damage caused by acetaminophen induction to normal. This was also confirmed by the histology study of the experimental group.</p> <p><strong>Conclusion:</strong> In conclusion, acetaminophen induced toxicity caused hepatotoxicity that may lead to liver damage and consumption of AEHr by albino rats helped protect acetaminophen toxicity and possible damage to the liver. Therefore, the results of this study suggest that <em>Hypoestes rosea have hepato</em>-protective properties in albino rats and should be subjected to more advanced studies, particularly in humans.</p> 2020-10-01T00:00:00+00:00 ##submission.copyrightStatement##