An Assessment of Anti-diabetic Effect of Gymnema sylvestre in Alloxan-induced Rat Model

Souvik Kumar Mandal

Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.

Sara Rahmat

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Kazi Sakib

Department of Pharmacy, Southeast University, Dhaka, Bangladesh.

Bornila Mehjabin

Department of Pharmaceutical Sciences, North South University, Plot # 15, Block #B, Bashundhara R/A, Dhaka ,1229, Bangladesh.

Tasnia Rahman

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Israt Jahan Rasna

Department of Botany, University of Chittagong, Bangladesh.

*Author to whom correspondence should be addressed.


Since the inception of human civilization, mankind has used herbal medicine for the purpose of healing. This study aimed to examine the antidiabetic efficacy and lipid profile of Gymnema sylvestre. We assessed the antidiabetic activity using the alloxan-induced diabetic technique. Regarding its antidiabetic effect, only the dosage of 900 mg/kg demonstrated statistically significant results (p<0.05). Regarding total cholesterol, High density Lipoprotein (HDL) and Low density Lipoprotein (LDL), the HDL level exhibited statistically significant findings in groups 3, 5, and 6. For triglyceride, SGOT (Serum glutamic oxaloacetic transaminase) and SGPT (Serum glutamate pyruvate transaminase), groups 4, 5, and 6 at doses of 300, 600, and 900 mg/kg, respectively, exhibited statistically significant results (p<0.05). The kidney function test revealed statistically significant outcomes (p<0.05) in groups 4, 5, and 6, which were given doses of 300, 600, and 900 mg/kg, respectively. The results suggest that Gymnema sylvestre has promise in developing standardized phytomedicine for treating individuals with diabetes, cardiovascular disease, liver disease, and renal sickness.

Keywords: Gymnema sylvestre, HDL, LDL, herbal medicine, triglyceride

How to Cite

Mandal , S. K., Rahmat , S., Sakib , K., Mehjabin , B., Rahman , T., & Rasna , I. J. (2024). An Assessment of Anti-diabetic Effect of Gymnema sylvestre in Alloxan-induced Rat Model. International Research Journal of Gastroenterology and Hepatology, 7(1), 29–36. Retrieved from


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