An Assessment of Anti-diabetic Effect of Gymnema sylvestre in Alloxan-induced Rat Model
Published: 2024-02-06
Page: 29-36
Issue: 2024 - Volume 7 [Issue 1]
Souvik Kumar Mandal
Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.
Sara Rahmat
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Kazi Sakib
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Bornila Mehjabin
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block #B, Bashundhara R/A, Dhaka ,1229, Bangladesh.
Tasnia Rahman
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Israt Jahan Rasna
Department of Botany, University of Chittagong, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Since the inception of human civilization, mankind has used herbal medicine for the purpose of healing. This study aimed to examine the antidiabetic efficacy and lipid profile of Gymnema sylvestre. We assessed the antidiabetic activity using the alloxan-induced diabetic technique. Regarding its antidiabetic effect, only the dosage of 900 mg/kg demonstrated statistically significant results (p<0.05). Regarding total cholesterol, High density Lipoprotein (HDL) and Low density Lipoprotein (LDL), the HDL level exhibited statistically significant findings in groups 3, 5, and 6. For triglyceride, SGOT (Serum glutamic oxaloacetic transaminase) and SGPT (Serum glutamate pyruvate transaminase), groups 4, 5, and 6 at doses of 300, 600, and 900 mg/kg, respectively, exhibited statistically significant results (p<0.05). The kidney function test revealed statistically significant outcomes (p<0.05) in groups 4, 5, and 6, which were given doses of 300, 600, and 900 mg/kg, respectively. The results suggest that Gymnema sylvestre has promise in developing standardized phytomedicine for treating individuals with diabetes, cardiovascular disease, liver disease, and renal sickness.
Keywords: Gymnema sylvestre, HDL, LDL, herbal medicine, triglyceride