Evaluation of the Effects of Ethanolic Extract of Ficus benghalensis on the Lipid Profile and Kidney Function in Rat Model
Published: 2024-02-03
Page: 22-28
Issue: 2024 - Volume 7 [Issue 1]
Puja Bhowmik
Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.
FM Sharifuzzaman Shohan
Department of Pharmacy, Primeasia University, Bangladesh.
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Tasin Islam Pranto
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi Dhaka-1205, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Tasnuva Sharmin Zaman
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Israt Jahan Rasna
Department of Botany, University of Chittagong, Bangladesh.
Rafat Tashin *
Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Almost since the dawn of human civilization, people have been employing herbal medicine as a means of treatment for various ailments. The anti-diabetic properties and lipid profile of Ficus benghalensis were investigated in this research. The anti-diabetic activity was measured by using the alloxan-induced diabetic approach. When compared to the control group, the doses of 500 mg/kg and 1000 mg/kg exhibited statistically significant (p<0.05) results in terms of their ability to inhibit the development of diabetes. In the case of total cholesterol, High density Lipoprotein (HDL) and Low density Lipoprotein (LDL) groups 3, 5 and 6 with doses of 100 mg/kg, 500 mg/kg, and 1000 mg exhibited outcomes that were statistically significant. In the case of triglycerides, the findings indicated that SGOT (Serum glutamic oxaloacetic transaminase) and SGPT (Serum glutamate pyruvate transaminase) group 4 and 5 with doses of 250 mg/kg and 500 mg/kg were statistically significant (p<0.05). The findings of the kidney function test showed that group 4, which received a dosage of 250mg/kg, had statistically significant (p<0.05) outcomes. According to the results, Ficus benghalensis has the potential to be used in the development of standardised phytomedicine for the treatment of patients suffering from diabetes, cardiovascular disease, liver disease, and renal sickness.
Keywords: Herbal medicine, Ficus benghalensis, SGPT, HDL, diabetes