Evaluation of the Effects of Ethanolic Extract of Ficus benghalensis on the Lipid Profile and Kidney Function in Rat Model
Published: 2024-02-03
Page: 22-28
Issue: 2024 - Volume 7 [Issue 1]
Puja Bhowmik
Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.
FM Sharifuzzaman Shohan
Department of Pharmacy, Primeasia University, Bangladesh.
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Tasin Islam Pranto
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi Dhaka-1205, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Tasnuva Sharmin Zaman
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Israt Jahan Rasna
Department of Botany, University of Chittagong, Bangladesh.
Rafat Tashin *
Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Almost since the dawn of human civilization, people have been employing herbal medicine as a means of treatment for various ailments. The anti-diabetic properties and lipid profile of Ficus benghalensis were investigated in this research. The anti-diabetic activity was measured by using the alloxan-induced diabetic approach. When compared to the control group, the doses of 500 mg/kg and 1000 mg/kg exhibited statistically significant (p<0.05) results in terms of their ability to inhibit the development of diabetes. In the case of total cholesterol, High density Lipoprotein (HDL) and Low density Lipoprotein (LDL) groups 3, 5 and 6 with doses of 100 mg/kg, 500 mg/kg, and 1000 mg exhibited outcomes that were statistically significant. In the case of triglycerides, the findings indicated that SGOT (Serum glutamic oxaloacetic transaminase) and SGPT (Serum glutamate pyruvate transaminase) group 4 and 5 with doses of 250 mg/kg and 500 mg/kg were statistically significant (p<0.05). The findings of the kidney function test showed that group 4, which received a dosage of 250mg/kg, had statistically significant (p<0.05) outcomes. According to the results, Ficus benghalensis has the potential to be used in the development of standardised phytomedicine for the treatment of patients suffering from diabetes, cardiovascular disease, liver disease, and renal sickness.
Keywords: Herbal medicine, Ficus benghalensis, SGPT, HDL, diabetes
How to Cite
References
Brison DW. Definition, diagnosis, and classification. Ameliorating Mental Disability: Questioning Retardation. 2017; 1–19.
M Ya. Lovkova, GN Buzuk, SM Sokolova, NIK. Chemical features of medicinal plants (Review)no title. Appl Biochem Microbiol. 2001;37(3):229–37.
Mim IJ, Peya FY, Chowdhury MM, Khan TR, Mandal SK, Maliha F, Alam M, Rahman T, Tashin R. An evaluation of anti-diabetic activity of ethanolic extract of asparagus racemosus in alloxan induced rat model. International Journal of Advances in Nephrology Research. 2023, Aug 2;6(1):60-8.
Bailey CJ, Day C. Antidiabetic drugs. Br JCardiol. 2003;10:128-136.
Grunberger G. Should side effect sinfluence the selection of antidiabetic therapies in type 2 diabetes? Curr DiabRep. 2017;17:21.
Mandal SK, Alam M, Chandra Ray M, Roy E, Rahman Khan T, Chowdhury MM, Sakib K, Jannat Mim I, Tahsin R. An assessment of analgesic and anti-inflammatory activity of manilkara zapota on rat model. South Asian Research Journal of Natural Products. 2023, Sep 4;6(3).
FM SS, Juliana AB, Bornila M, Puja B, Nur-Neasha D, Rafat T. An assessment of hepato-protective activity of psidium guajava fruit extract against hepatic injured rodent model. Asian Journal of Medical Principles and Clinical Practice. 2023, Oct 7;6(2):240-5.
Rupak MA, Chowdhury MM, Shurovi FS, Ferdous J, Tahsin MR, Sarif S, Hasan MM, Chowdhury JA, Kabir S, Chowdhury AA, Aktar F. An evaluation of analgesic and anti-inflammatory activity of ethanolic extract of cynodon dactylon on stressed rodent model. Biomedical Journal of Scientific & Technical Research. 2022; 42(3):33550-7.
Bhaskara Rao KV, Ojha V, Preeti, Kumar G, Karthik L. Phytochemical composition and antioxidant activity of Ficus benghalensis (Moraceae) leaf extract. Journal of Biologically Active Products from Nature. 2014, May 4;4(3):236-48.
Gopukumar ST, Alexander P, Jainamboo M, Praseetha P. Phytochemical screening and FT-IR analysis of Ficus benghalensis fruits. International Journal of Pharmacognosy and Phytochemical Research. 2016;8(9):1529-34.
Gopukumar ST, Praseetha PK. Ficus benghalensis Linn–the sacred Indian medicinal tree with potent pharmacological remedies. Int. J. Pharm. Sci. Rev. Res. 2015, May;32(37):223-7.
Saraswathi S, Senthamarai R, Sundari S. Antidiabetic activity of leaves extract of Ficus benghalensis linn on alloxan induced diabeteic rats. International Journal of Pharmacology & Biological Sciences. 2013, Dec 1;7(3).
Sonkamble VV, Kamble LH. Antidiabetic potential and identification of phytochemicals from Tinospora cordifolia. American Journal of Phytomedicine and Clinical Therapeutics. 2015;3(1):97-110.
Sathiyaseelan A, Park S, Saravanakumar K, Mariadoss AV, Wang MH. Evaluation of phytochemicals, antioxidants, and antidiabetic efficacy of various solve ntfractions of gynura procumbens (Lour.) Merr. Process Biochemistry. 2021; 111:51-62.
Madiwalar VS, Dwivedi PS, Patil A, Gaonkar SM, Kumbhar VJ, Khanal P, Patil BM. Ficus benghalensis promotes the glucose uptake-evidence with In silico and In vitro. Journal of Diabetes & Metabolic Disorders. 2022, Jun;21(1):429-38.
Abusufyan S, Ibrahim M, Mohib K. Comparative In vitro antidiabetic and antioxidant activity of various extracts of ficus species. Pharmacognosy Journal. 2018;10(2).
Khanal P, Patil BM. Integration of In silico, In vitro and ex vivo pharmacology to decode the anti-diabetic action of Ficus benghalensis L. bark. Journal of Diabetes & Metabolic Disorders. 2020, Dec;19:1325-37.
Ponnuvel Deepa, Kandhasamy Sowndhararajan, Songmun Kim, Se Jin Park, A role of ficus species in the management of diabetes mellitus: A review, Journal of Ethnopharmacology. 2018, 6 April;215:210-232. Available:https://doi.org/10.1016/j.jep.2017.12.045
Hamed MA. Beneficial effect of ficus religiosa Linn. on high-fat-diet- induced hypercholesterolemia in rats. Food chemistry. 2011, Nov 1;129(1):162-70.1
Baheti JR, Goyal RK. Evaluation of hepatoprotective activity of Ficus bengalensis. Int J Res Pharm Sci. 2011; 2(4):522-.
Shinde M, Shete RV, Kore KJ, Attal AR. Hepatoprotective activity of Ficus bengalensis Linn leaves. Journal of Current Pharma Research. 2012;2(2): 503.
Ramasamy A, Kathiresan K. Acute oral toxicity study of ethyl acetate extracts of Ficus benghalensis aerial ROOTS. Biomedical and Pharmacology Journal. 2023 Mar 21;16(1):43-51.