Comparison of Intravenous and Topical Injection Administration Mesenchymal Stem Cell Secretome to Restrain Gastrointestinal Anastomosis Leakage: A Review

Joko Wibowo Sentoso *

Department of Surgery, Faculty of Medicine, Sebelas Maret University, Dr. Moewardi Hospital, Surakarta, Indonesia.

Agung Putra

Stem Cell and Cancer Research, Indonesia.

Ida Bagus Budhi SA

Department of Digestive Surgery, Faculty of Medicine, Sebelas Maret University, Dr. Moewardi Hospital, Surakarta, Indonesia.

Anung Noto Nugroho

Department of Digestive Surgery, Faculty of Medicine, Sebelas Maret University, Dr. Moewardi Hospital, Surakarta, Indonesia.

Suryo Wahyu Raharjo

Department of Digestive Surgery, Faculty of Medicine, Sebelas Maret University, Dr. Moewardi Hospital, Surakarta, Indonesia.

*Author to whom correspondence should be addressed.


Abstract

Intestinal anastomosis is one of the most commonly performed gastrointestinal surgical procedures, especially in emergencies and is commonly performed in elective procedures when resection is performed for benign or malignant lesions of the gastrointestinal tract. One of the important postoperative complications that causes significant morbidity and adversely affects the length of hospital stay is anastomotic leak after gastrointestinal anastomosis. Recently, developments in regenerative medicine applied to gastrointestinal anastomoses show promise for improving anastomotic healing. Recent studies have demonstrated that stem cell-derived secretomes can potentially enhance anastomized tissue regeneration without the safety and ethical limitations of stem cell transplantation. A study showed that the MSC secretome significantly promoted cell proliferation and survival in a dose-dependent manner and resulted in the controlled release of growth factors. Mesenchymal stem cell (MSC)-derived secretomes have controlled delivery of bioactive factors, and have potential in improving healing of intestinal anastomoses. In this review, we discuss the comparison of the therapeutic effects of the MSC secretome given by topical injection and the MSC secretome injected intravenously in terms of healing and anastomotic resistance.

Keywords: Mesenchymal stem cells, mesenchymal stem cells secretome, intestinal anastomosis leakage, anastomotic resistance


How to Cite

Sentoso, Joko Wibowo, Agung Putra, Ida Bagus Budhi SA, Anung Noto Nugroho, and Suryo Wahyu Raharjo. 2025. “Comparison of Intravenous and Topical Injection Administration Mesenchymal Stem Cell Secretome to Restrain Gastrointestinal Anastomosis Leakage: A Review”. International Research Journal of Gastroenterology and Hepatology 8 (1):1-8. https://doi.org/10.9734/irjgh/2025/v8i1107.

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